© 2018 MEDIWISS Analytic GmbH
AllergyScreen® and AlleisaScreen® are two test systems to detect allergen-specific IgE in human serum. Customers can be provided with the necessary test strips and the corresponding hard- and software (camera, scanner, testing equipment, robotics).

Comparative studies

A comparison with an established single allergen determination System (SADS) and skin test has shown that the Allergy-Screen® System offers a highly effective method for determining a patient‘s comprehensive specific sensitisation pattern. The sensitivity and specificity of the system is very similar to skin testing, and corresponds to a conventional single allergen system.

What‘s more, the Allergy-/Alleisa-Screen® systems achieve precise results at a low cost and with a minimum material expenditure.

A complete study overview is available for registered customers. Visit the customer service area for further information.

AllergyScreen® in comparison with a single allergen determination System (internal studies)

Latex
Sensitivity: 92.9 %
Specifity: 100.0 %
Accuracy: 92.9 %
Bee
Sensitivity: 93.8 %
Specifity: 100.0 %
Accuracy: 97.2 %
Wasp
Sensitivity: 95.7 %
Specifity: 78.6 %
Accuracy: 89.2 %
Food
Sensitivity: 76.8 %
Specifity: 77.5 %
Accuracy: 77.1 %
IgG4
Sensitivity: 79.6 %
Specifity: 75.0 %
Accuracy: 79.1 %

Comparison of a single allergen determination system (SADS), skin-prick test and AllergyScreen® (Inhalative allergens 142 sera tested) (Kersten, 2002)

Sensitivity
Prick-test/AllergyScreen®: 95.1 %
Prick-test/SADS: 95.8 %
SADS /AllergyScreen®: 84.3 %
Specifity
Prick-test/AllergyScreen®: 80.2 %
Prick-test/SADS: 76.1 %
SADS /AllergyScreen®: 95.0 %
Accuracy
Prick-test/AllergyScreen®: 88.3 %
Prick-test/SADS: 87.5 %
SADS /AllergyScreen®: 90.6 %

Inter-assay and Intra-assay variations - IgE and lgG4 (n=1O)

Inter-assay variation IgG4 4.0 %
Intra-assay variation IgG4 1.7 %
Inter-assay variation IgE 3.9 %
Intra-assay variation IgE 4.5 %
Inter-batch variation IgE 8.8 %

Bibliographic data of some public studies

  • Kersten, W.; (2002): Comparison of the AllergyScreen (MEDIWISS Analytic, Moers) with the Skin Test (HAL, Düsseldorf -in-vivo) and the CAP-System (Pharmacia, Freiburg -in-vitro).- Allergologie 25, 4, 203-208
  • Park, D.S.; Cho, J.H.; Lee, E.L.; Ko, O.S.; Kim, R.K.; Choi, S.I.; Lee, Y.J.; (2004): Detection Rate of Allergen-Specific IgE by Multiple Antigen Simultaneous Test-Immunoblot Assay. - Korean J Lab Med 24: 131-8
  • Herzum, I.; Blümer, N.; Kersten, W.; Renz, H.; (2005): Diagnostic and analytical performance of a screening panel for allergy.- Clin.Chem.Lab. Med 43 (9), 963-966
  • Shoormasti, R.S.; Fazlollahi, M.R.; Kaznemnejad, A.; Movahedi, M.; Tayebi, B.; Yazdanyar, Z.; Azadi, Z.; Pourpak, Z.; Moin, M.; (2018): Accuracy of immunoblotting assay for detection of specific IgE compared with ImmunoCAP in allergie patients.- Electronic Physician 10, 2: 6327-6332
  • John, H.; Borae, G.; Jeong-Ho, K.A.; Hyon-Suk, K.; (2016): Comparison and clinical utility evaluation of four multiple allergen simultaneous tests including two newly introduced fully automated analyzers.- Practical Laboratory Medicine 4, 50–61
  • Jiang, X.-D.; Li, G-L.; Dong, Z.; Zhi, D-D.; (2011): Correlation analysis of two serum-specific Immunoglobulin E test systems and skin-prick test in allergic rhinitis patients from northeast China.- Am Journal of Rhinology & Allergy 25:116-119
  • Miao, Q.; Lio, Y.; Ren, Y.; Li. Z.; Xu, W.; Guan, H.; Wang, Y.; Xiang, L.; (2018): Monozentrische retrospektive Analyse von Sensibilisierungsprofilen in einem Zentrum der pädiatrischen Tertiärversorgung in Peking, China.- Allergologie 41/5:191-198