MEDIWISS ANALYTIC GmbH
AllergyScreen® and AlleisaScreen® are two test systems to detect allergen-specific IgE in human serum/plasma. Customers can be provided with the necessary test strips and the corresponding hard- and software (scanner, testing equipment).
Comparative studies
A comparison with an established single allergen determination System (SADS) and skin test has shown that the Allergy-Screen® System offers a highly effective method for determining a patient‘s comprehensive specific sensitisation pattern. The sensitivity and specificity of the system is very similar to skin testing, and corresponds to a conventional single allergen system.
What‘s more, the Allergy-/Alleisa-Screen® systems achieve precise results at a low cost and with a minimum material expenditure.
A complete study overview is available for registered customers. Visit the customer service area for further information.
AllergyScreen® in comparison with a single allergen determination System (internal studies)
| Latex | |
|---|---|
| Sensitivity: | 92.9 % |
| Specifity: | 100.0 % |
| Accuracy: | 92.9 % |
| Bee | |
| Sensitivity: | 93.8 % |
| Specifity: | 100.0 % |
| Accuracy: | 97.2 % |
| Wasp | |
| Sensitivity: | 95.7 % |
| Specifity: | 78.6 % |
| Accuracy: | 89.2 % |
| Food | |
| Sensitivity: | 76.8 % |
| Specifity: | 77.5 % |
| Accuracy: | 77.1 % |
| IgG4 | |
| Sensitivity: | 79.6 % |
| Specifity: | 75.0 % |
| Accuracy: | 79.1 % |
Comparison of a single allergen determination system (SADS), skin-prick test and AllergyScreen® (Inhalative allergens 142 sera tested) (Kersten, 2002)
| Sensitivity | |
|---|---|
| Prick-test/AllergyScreen®: | 95.1 % |
| Prick-test/SADS: | 95.8 % |
| SADS /AllergyScreen®: | 84.3 % |
| Specifity | |
| Prick-test/AllergyScreen®: | 80.2 % |
| Prick-test/SADS: | 76.1 % |
| SADS /AllergyScreen®: | 95.0 % |
| Accuracy | |
| Prick-test/AllergyScreen®: | 88.3 % |
| Prick-test/SADS: | 87.5 % |
| SADS /AllergyScreen®: | 90.6 % |
Inter-assay and Intra-assay variations - IgE and lgG4 (n=1O)
| Inter-assay variation IgG4 | 4.0 % |
| Intra-assay variation IgG4 | 1.7 % |
| Inter-assay variation IgE | 3.9 % |
| Intra-assay variation IgE | 4.5 % |
| Inter-batch variation IgE | 8.8 % |
Bibliographic data of some public studies
- Kersten, W.; (2002): Comparison of the AllergyScreen (MEDIWISS Analytic, Moers) with the Skin Test (HAL, Düsseldorf -in-vivo) and the CAP-System (Pharmacia, Freiburg -in-vitro).- Allergologie 25, 4, 203-208
- Park, D.S.; Cho, J.H.; Lee, E.L.; Ko, O.S.; Kim, R.K.; Choi, S.I.; Lee, Y.J.; (2004): Detection Rate of Allergen-Specific IgE by Multiple Antigen Simultaneous Test-Immunoblot Assay. - Korean J Lab Med 24: 131-8
- Herzum, I.; Blümer, N.; Kersten, W.; Renz, H.; (2005): Diagnostic and analytical performance of a screening panel for allergy.- Clin.Chem.Lab. Med 43 (9), 963-966
- Shoormasti, R.S.; Fazlollahi, M.R.; Kaznemnejad, A.; Movahedi, M.; Tayebi, B.; Yazdanyar, Z.; Azadi, Z.; Pourpak, Z.; Moin, M.; (2018): Accuracy of immunoblotting assay for detection of specific IgE compared with ImmunoCAP in allergie patients.- Electronic Physician 10, 2: 6327-6332
- John, H.; Borae, G.; Jeong-Ho, K.A.; Hyon-Suk, K.; (2016): Comparison and clinical utility evaluation of four multiple allergen simultaneous tests including two newly introduced fully automated analyzers.- Practical Laboratory Medicine 4, 50–61
- Jiang, X.-D.; Li, G-L.; Dong, Z.; Zhi, D-D.; (2011): Correlation analysis of two serum-specific Immunoglobulin E test systems and skin-prick test in allergic rhinitis patients from northeast China.- Am Journal of Rhinology & Allergy 25:116-119
- Miao, Q.; Lio, Y.; Ren, Y.; Li. Z.; Xu, W.; Guan, H.; Wang, Y.; Xiang, L.; (2018): Monozentrische retrospektive Analyse von Sensibilisierungsprofilen in einem Zentrum der pädiatrischen Tertiärversorgung in Peking, China.- Allergologie 41/5:191-198